Publications
2024
Jonas De Breuck, Michael Streiber, Michael Ringleb, Dennis Schröder, Natascha Herzog, Ulrich S. Schubert, Stefan Zechel, Anja Traeger, Meike N. Leiske: Amino-Acid-Derived Anionic Polyacrylamides with Tailored Hydrophobicity : Physicochemical Properties and Cellular Interactions. In: ACS Polymers Au, (2024). - .
doi:10.1021/acspolymersau.3c00048
Anne-Catherine Lehnen, Sergio Kogikoski Jr., Till Stensitzki, Ahmad AlSawaf, Alain M. Bapolisi, Martin Wolff, Jonas De Breuck, Henrike M. Müller-Werkmeister, Salvatore Chiantia, Ilko Bald, Meike N. Leiske, Matthias Hartlieb: Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity. In: Advanced Functional Materials, 34 (2024). - .
doi:10.1002/adfm.202312651
Cevin P. Braksch, Anne-Catherine Lehnen, Alain M. Bapolisi, Johannes Gurke, Jonas De Breuck, Meike N. Leiske, Matthias Hartlieb: Staphylococcus aureus selective antimicrobial polymers based on an arginine-derived monomer. In: Journal of Polymer Science, 62 (2024). - S. 132-145.
doi:10.1002/pol.20230591
Prosper P. Mapfumo, Jana I. Solomun, Friedrich Becker, Elisabeth Moek, Meike N. Leiske, Lenhard K. Rudolph, Johannes C. Brendel, Anja Traeger: Vitamin B3 Containing Polymers for Nanodelivery. In: Macromolecular Bioscience, (2024). - .
doi:10.1002/mabi.202400002
2023
Meike N. Leiske, Bruno G. De Geest, Richard Hoogenboom: Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells. In: Bioactive Materials, 24 (2023). - S. 524-534.
doi:10.1016/j.bioactmat.2023.01.005
Meike N. Leiske: Poly(2-oxazoline)-derived star-shaped polymers as potential materials for biomedical applications : A review. In: European Polymer Journal, 185 (2023). - .
doi:10.1016/j.eurpolymj.2023.111832
Meike N. Leiske, Ronak Singha, Somdeb Jana, Bruno G. De Geest, Richard Hoogenboom: Amidation of methyl ester-functionalised poly(2-oxazoline)s as a powerful tool to create dual pH- and temperature-responsive polymers as potential drug delivery systems. In: Polymer Chemistry, 14 (2023). - S. 2034-2044.
doi:10.1039/D3PY00050H
Meike N. Leiske, Christopher Künneth, Jonas De Breuck, Bruno G. De Geest, Richard Hoogenboom: Amphiphilic Zwitterionic Bioderived Block Copolymers from Glutamic Acid and Cholesterol : Ability to Form Nanoparticles and Serve as Vectors for the Delivery of 6-Mercaptopurine. In: Macromolecular Chemistry and Physics, 224 (2023). - .
doi:10.1002/macp.202300200
Zihnil A. I. Mazrad, Meike N. Leiske, Rico F. Tabor, Joseph A. Nicolazzo, Kristian Kempe: Comparison of the Anti-inflammatory Activity and Cellular Interaction of Brush Polymer–N-Acetyl Cysteine Conjugates in Human and Murine Microglial Cell Lines. In: Molecular Pharmaceutics, 20 (2023). - S. 2686-2701.
doi:10.1021/acs.molpharmaceut.3c00140
Ronald Merckx, Jana Becelaere, Ella Schoolaert, Olmo Frateur, Meike N. Leiske, Daniël Peeters, Florica Adriana Jerca, Valentin Victor Jerca, Karen De Clerck, Richard Hoogenboom: Poly(2-isoproprenyl-2-oxazoline)-Based Reactive Hydrophilic Cross-Linked Nanofiber Networks as the Basis for Colorimetric Continuous Meat Freshness Monitoring Sensors. In: Chemistry of Materials, 35 (2023). - S. 7079-7093.
doi:10.1021/acs.chemmater.3c01355
2022
Joachim F. R. Van Guyse, Meike N. Leiske, Jente Verjans, Yann Bernhard, Richard Hoogenboom: Accelerated Post-Polymerization Amidation of Polymers with Side-Chain Ester Groups by Intramolecular Activation. In: Angewandte Chemie International Edition, 61 (2022). - .
doi:10.1002/anie.202201781
Z. Ma, S. W. Wong, H. Forgham, L. Esser, M. Lai, Meike N. Leiske, K. Kempe, G. Sharbeen, J. Youkhana, F. Mansfeld, J. F. Quinn, P. A. Phillips, T. P. Davis, M. Kavallaris, J. A. McCarroll: Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth. In: Biomaterials, 285 (2022). - .
doi:10.1016/j.biomaterials.2022.121539
Meike N. Leiske, Kristian Kempe: A Guideline for the Synthesis of Amino-Acid-Functionalized Monomers and Their Polymerizations. In: Macromolecular Rapid Communications, 43 (2022). - .
doi:10.1002/marc.202100615
Sarigama Rajesh, Meike N. Leiske, Victoria Leitch, Jiali Zhai, Calum J. Drummond, Kristian Kempe, Nhiem Tran: Lipidic poly(2-oxazoline)s as PEG replacement steric stabilisers for cubosomes. In: Journal of Colloid and Interface Science, 623 (2022). - S. 1142-1150.
doi:10.1016/j.jcis.2022.04.158
Zihnil A. I. Mazrad, May Lai, Thomas P. Davis, Joseph A. Nicolazzo, Kristofer J. Thurecht, Meike N. Leiske, Kristian Kempe: Protected amine-functional initiators for the synthesis of α-amine homo- and heterotelechelic poly(2-ethyl-2-oxazoline)s. In: Polymer Chemistry, 13 (2022). - S. 4436-4445.
doi:10.1039/D2PY00649A
Meike N. Leiske, Zihnil A. I. Mazrad, Aykut Zelcak, Kanu Wahi, Thomas P. Davis, Joshua A. McCarroll, Jeff Holst, Kristian Kempe: Zwitterionic Amino Acid-Derived Polyacrylates as Smart Materials Exhibiting Cellular Specificity and Therapeutic Activity. In: Biomacromolecules, 23 (2022). - S. 2374-2387.
doi:10.1021/acs.biomac.2c00143
2021
Veerasikku Gopal Deepagan, Meike N. Leiske, Nicholas L. Fletcher, David Rudd, Terence Tieu, Nicholas Kirkwood, Kristofer J. Thurecht, Kristian Kempe, Nicolas H. Voelcker, Anna Cifuentes-Rius: Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers : Toward Enhanced Monodispersity and Stability. In: Nano Letters, 21 (2021). - S. 476-484.
doi:10.1021/acs.nanolett.0c03930
Meike N. Leiske, May Lai, Thakshila Amarasena, Thomas P. Davis, Kristofer J. Thurecht, Stephen J. Kent, Kristian Kempe: Interactions of core cross-linked poly(2-oxazoline) and poly(2-oxazine) micelles with immune cells in human blood. In: Biomaterials, 274 (2021). - .
doi:10.1016/j.biomaterials.2021.120843
Zihnil A. I. Mazrad, Baptiste Schelle, Joseph A. Nicolazzo, Meike N. Leiske, Kristian Kempe: Nitrile-Functionalized Poly(2-oxazoline)s as a Versatile Platform for the Development of Polymer Therapeutics. In: Biomacromolecules, 22 (2021). - S. 4618-4632.
doi:10.1021/acs.biomac.1c00923
2020
Meike N. Leiske, Ayaat M. Mahmoud, Nicole M. Warne, Jeroen A. C. M. Goos, Sagrario Pascual, Véronique Montembault, Laurent Fontaine, Thomas P. Davis, Michael R. Whittaker, Kristian Kempe: Poly(2-isopropenyl-2-oxazoline) : a structural analogue to poly(vinyl azlactone) with Orthogonal Reactivity. In: Polymer Chemistry, 11 (2020). - S. 5681-5692.
doi:10.1039/D0PY00861C
Meike N. Leiske, Julia A. Walker, Aadarash Zia, Nicholas L. Fletcher, Kristofer J. Thurecht, Thomas P. Davis, Kristian Kempe: Synthesis of biscarboxylic acid functionalised EDTA mimicking polymers and their ability to form Zr(iv) chelation mediated nanostructures. In: Polymer Chemistry, 11 (2020). - S. 2799-2810.
doi:10.1039/D0PY00304B
2019
Anne-Kristin Trützschler, Meike N. Leiske, Maria Strumpf, Johannes C. Brendel, Ulrich S. Schubert: One-Pot Synthesis of Block Copolymers by a Combination of Living Cationic and Controlled Radical Polymerization. In: Macromolecular Rapid Communications, 40 (2019). - .
doi:10.1002/marc.201800398
Peng Wei, Gauri Gangapurwala, David Pretzel, Meike N. Leiske, Limin Wang, Stephanie Hoeppener, Stephanie Schubert, Johannes C. Brendel, Ulrich S. Schubert: Smart pH-Sensitive Nanogels for Controlled Release in an Acidic Environment. In: Biomacromolecules, 20 (2019). - S. 130-140.
doi:10.1021/acs.biomac.8b01228
Nora Engel, Michael Dirauf, Susanne Seupel, Meike N. Leiske, Stephanie Schubert, Ulrich S. Schubert: Utilization of 4-(trifluoromethyl)benzenesulfonates as Counter Ions Tunes the Initiator Efficiency of Sophisticated Initiators for the Preparation of Well-Defined poly(2-oxazoline)s. In: Macromolecular Rapid Communications, 40 (2019). - .
doi:10.1002/marc.201900094
2018
David Hertz, Meike N. Leiske, Thomas Wloka, Anja Traeger, Matthias Hartlieb, Michael M. Kessels, Stephanie Schubert, Britta Qualmann, Ulrich S. Schubert: Comparison of random and gradient amino functionalized poly(2-oxazoline)s : Can the transfection efficiency be tuned by the macromolecular structure?. In: Journal of Polymer Science Part A: Polymer Chemistry, 56 (2018). - S. 1210-1224.
doi:10.1002/pola.29000
Meike N. Leiske, Fabian H. Sobotta, Friederike Richter, Stephanie Hoeppener, Johannes C. Brendel, Anja Traeger, Ulrich S. Schubert: How To Tune the Gene Delivery and Biocompatibility of Poly(2-(4-aminobutyl)-2-oxazoline) by Self- and Coassembly. In: Biomacromolecules, 19 (2018). - S. 748-760.
doi:10.1021/acs.biomac.7b01535
Mandy Grube, Meike N. Leiske, Ulrich S. Schubert, Ivo Nischang: POx as an Alternative to PEG? A Hydrodynamic and Light Scattering Study. In: Macromolecules, 51 (2018). - S. 1905-1916.
doi:10.1021/acs.macromol.7b02665
Doerte Hoelzer, Meike N. Leiske, Matthias Hartlieb, Tanja Bus, David Pretzel, Stephanie Hoeppener, Kristian Kempe, René Thierbach, Ulrich S. Schubert: Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment. In: Oncotarget, 9 (2018). - S. 22316-22331.
doi:10.18632/oncotarget.24806
2017
Meike N. Leiske, Anne-Kristin Trützschler, Sabine Armoneit, Pelin Sungur, Stephanie Hoeppener, Marc Lehmann, Anja Traeger, Ulrich S. Schubert: Mission ImPOxable : or the unknown utilization of non-toxic poly(2-oxazoline)s as cryoprotectants and surfactants at the same time. In: Journal of Materials Chemistry B, 5 (2017). - S. 9102-9113.
doi:10.1039/C7TB02443F
Tessa Lühmann, Marcel Schmidt, Meike N. Leiske, Valerie Spieler, Tobias C. Majdanski, Mandy Grube, Matthias Hartlieb, Ivo Nischang, Stephanie Schubert, Ulrich S. Schubert, Lorenz Meinel: Site-Specific POxylation of Interleukin-4. In: ACS Biomaterials Science & Engineering, 3 (2017). - S. 304-312.
doi:10.1021/acsbiomaterials.6b00578
Matthias Hartlieb, Tanja Bus, Joachim Kübel, David Pretzel, Stephanie Hoeppener, Meike N. Leiske, Kristian Kempe, Benjamin Dietzek, Ulrich S. Schubert: Tailoring Cellular Uptake and Fluorescence of Poly(2-oxazoline)-Based Nanogels. In: Bioconjugate Chemistry, 28 (2017). - S. 1229-1235.
doi:10.1021/acs.bioconjchem.7b00067
2016
Meike N. Leiske, Matthias Hartlieb, Fabian H. Sobotta, Renzo M. Paulus, Helmar Görls, Peter Bellstedt, Ulrich S. Schubert: Cationic ring-opening polymerization of protected oxazolidine imines resulting in gradient copolymers of poly(2-oxazoline) and poly(urea). In: Polymer Chemistry, 7 (2016). - S. 4924-4936.
doi:10.1039/C6PY00785F
2015
Meike N. Leiske, Matthias Hartlieb, Christian Paulenz, David Pretzel, Martin Hentschel, Christoph Englert, Michael Gottschaldt, Ulrich S. Schubert: Lab in a Tube : Purification, Amplification, and Detection of DNA Using Poly(2-oxazoline) Multilayers. In: Advanced Functional Materials, 25 (2015). - S. 2458-2466.
doi:10.1002/adfm.201404510